C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/04 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07C 229/16 (2006.01) C07F 5/00 (2006.01) C07F 15/02 (2006.01)
Patent
CA 2116867
A compound of the following formula Image wherein m is an integer of 1 to 3, R1, and R2 are the same or different and each is hydrogen atom or lower alkyl, and Ra, R4, R5 and R6 are the same or different and each is hydroxy or a group of the formula Image (wherein n is 0 or 1, X is -NH- or -0-, Y is alkylene, A is hydrogen atom, lower alkyl, lower alkoxy, halogen atom or trifluoromethyl, and B is alkyl or alkenyl), with the proviso that two or three of R3, R4, R5 and Ra are hydroxyl groups and that when two of them are hydroxyl groups, the cases where R3 and R5 are hydroxy, and R4, and Re are hydroxy are excluded; a complex compound comprising said compound and a metallic atom; and a diagnostic agent containing said complex compound. The above compound is useful as a chelating agent and the complex compound comprising said compound and a metallic atom exhibits superior characteristics as a contrast medium for image diagnosis.
Imagawa Takashi
Kim Sang-Won
Kozuka Takahiro
Marukawa Taro
Miyagi Ikuko
Fetherstonhaugh & Co.
The Green Cross Corporation
Welfide Corporation
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