C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/30 (2006.01) A61K 49/06 (2006.01) A61K 49/10 (2006.01) C07F 9/48 (2006.01)
Patent
CA 2210060
The invention relates to novel chelating ligands which incorporate a tripodal backbone. More particularly, the invention pertains to novel tripodal ligands which form coordination compounds with a variety of metal ions, particularly, but not exclusively, trivalent metal ions and lanthanide metal ions, which are useful in nuclear medicine. A novel amine phosphinate tripodal ligand, a chelating ligand and a process therefor involving a metal ion and particularly a trivalent metal ion of the group 13 metals and the rare earths. The process comprises complexing Tc or Re or any one of the group 13 metals, Al, Ga and In, and any one of the rare earths, Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, En, Tm, Yb and Lu, with an amine phosphinate trirodal ligand.
L'invention concerne des coordinats chélateurs nouveaux ayant un squelette tripode. Plus particulièrement, l'invention a trait aux coordinats tripodes nouveaux qui forment des complexes avec une diversité d'ions métalliques, particulièrement mais non exclusivement des ions de métaux trivalents et des ions de lanthanides, qui sont utiles en médecine nucléaire. Un coordinat tripode nouveau d'aminophosphinate, un coordinat chélateur et un processus associé mettant en jeu un ion métallique et particulièrement un ion de métal trivalent des métaux du groupe 13 et des terres rares. Le processus consiste à complexer le Tc ou le Re ou n'importe lequel des métaux du groupe 13, Al, Ga et In, et n'importe laquelle des terres rares, Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, En, Tm, Yb et Lu, avec un coordinat tripode d'aminophosphinate.
Lowe Mark P.
Orvig Chris
Oyen Wiggs Green & Mutala Llp
University Of British Columbia
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