C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/86 (2006.01) A61K 31/216 (2006.01) A61K 31/235 (2006.01) A61K 31/25 (2006.01) A61K 31/343 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07C 69/732 (2006.01) C07C 69/94 (2006.01)
Patent
CA 2679955
Novel compounds, their methods of preparation and use in therapies related to cancer and inflammation are provided. Compounds comprise esters of cinnamic acid, vanillic acid and 4- hyrdoxy cinnamic acid and derivatives and salts thereof. Compounds with novel benzofuran lignan structure as a potent antimitotic agent and inducer of apoptosis are provided. Formulations and methods for treatment of diseases mediated by NF-kappaB are also provided.
L'invention concerne de nouveaux composés, leurs procédés de préparation et leur utilisation dans des traitements associés au cancer et à l'inflammation. Lesdits composés comprennent des esters d'acide cinnamique, d'acide vanillique et d'acide 4-hydroxy-cinnamique ainsi que des dérivés et des sels correspondants. L'invention concerne également des composés présentant une nouvelle structure benzofurane lignane, utilisés comme puissant agent antimitotique et comme puissant inducteur de l'apoptose. L'invention se rapporte en outre à des préparations et des méthodes de traitement de maladies médiées par le NF-kappaB.
Bose Julie Saha
Gangan Vijay
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Reliance Life Sciences Pvt. Ltd.
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