C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/785 (2006.01) C12N 5/10 (2006.01) C12N 9/72 (2006.01)
Patent
CA 2588965
The present invention relates to recombinant chimeric proteins comprising a surfactant protein precursor N-terminally fused to a plasminogen activator or comprising a mature surfactant protein N-terminally or C-terminally fused to a plasminogen activator. The invention is also directed to the corresponding nucleic acid molecules encoding such fusion proteins as well as to a method for their production. The invention further refers to a pharmaceutical composition comprising such a fusion protein and to pharmacological uses of an inventive fusion protein for the prevention and/or treatment of inflammatory and interstitial lung diseases.
L'invention concerne des protéines chimères recombinées comprenant un précurseur de protéine tensioactive à terminaison N fusionnée à un activateur du plasminogène ou comprenant une protéine tensioactive mature à terminaison N ou C fusionnée à un activateur du plasminogène. L'invention concerne également les molécules d'acides nucléiques correspondantes codant pour lesdites protéines de fusion ainsi que leur procédé de production. L'invention concerne en outre une composition pharmaceutique comprenant une desdites protéines de fusion et les utilisations pharmacologiques de celles-ci dans la prévention et/ou le traitement de maladies inflammatoires et pulmonaires interstitielles.
Guenther Andreas
Magdolen Viktor
Markart Philipp
Ruppert Clemens
Seeger Werner
Blake Cassels & Graydon Llp
Justus-Liebig-Universitaet Giessen
Seeger Werner
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