Novel chimeric proteins and methods for using the same

Details Novel chimeric proteins and methods for using the same Novel chimeric proteins and methods for using the same

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2395945

Novel chimeric proteins are disclosed. The proteins comprise at least two portions. The first portion binds to a first cell and decreases the cell's ability to send a trans signal to a second cell; the second portion sends its own trans signal to the second cell. Methods for making and using these proteins in the treatment of cancer, viral infections, autoimmune and alloimmune diseases are also disclosed, as are pharmaceutical formulations comprising the novel chimeric proteins and genes. Either the proteins themselves or a genetic sequence encoding the protein can be administered. Other methods are also disclosed in which two molecular components result in decrement of a first trans signal from a first cell and the conferring of a second trans signal to a second cell.

L'invention concerne des protéines chimères comprenant au moins deux parties. La première partie se lie à une première cellule et diminue la capacité de cette cellule à envoyer un signal trans à une seconde cellule. La seconde partie envoie son propre signal trans à la seconde cellule. L'invention concerne en outre des procédés relatifs à l'utilisation des protéines considérées pour le traitement du cancer, des infections virales, des maladies auto-immunes et allo-immunes, ainsi que des formulations pharmaceutiques renfermant les protéines chimères décrites et les gènes correspondants. On peut administrer les protéines elles-mêmes ou bien une séquence génétique codant les protéines. L'invention concerne également d'autres procédés qui consistent à utiliser deux composantes moléculaires pour diminuer un premier signaltrans émanant d'une première cellule et conférer un second signal trans à une seconde cellule.

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