C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/06 (2006.01) A61K 31/135 (2006.01) A61K 31/46 (2006.01)
Patent
CA 2641916
This invention relates to novel chromen-2-one derivatives of formula (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. Formula (I) wherein Q represents a chromen-2-one group; which chromen-2-one group is optionally substituted with one or more substituents independently selected from the group consisting of: halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl; R1 represents hydrogen or alkyl; which alkyl is optionally substituted with one or more substituents independently selected from the group consisting of: halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl; and R2 and R3 together form - (CH2)-(CH2)- or -(CH)=(CH)-.
L'invention concerne des nouveaux dérivés de chromen-2-one représentés par la formule (I), qui conviennent comme inhibiteurs de recaptage de neurotransmetteurs monoamine. Selon d'autres aspects, cette invention concerne l'utilisation des ces composés à des fins thérapeutiques et des compositions pharmaceutiques comprenant les composés de l'invention. Dans la formule (I), Q représente un groupe chromem-2-one, lequel groupe est éventuellement substitué par un ou plusieurs substituants pris indépendamment dans le groupe constitué de halo, trifluorométhyle, trifluorométhoxy, cyano, hydroxy, amino, nitro, alkoxy,cycloalkoxy, alkyle, cycloalkyle, cycloalkylalkyle, alcényle et alkynyle; R1 représente hydrogène ou alkyle, lequel alkyle est éventuellement substitué par un ou plusieurs substituants pris indépendamment dans le groupe constitué de halo, trifluorométhyle, trifluorométhoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyle, cycloalkyle, cycloalkylalkyle, alcényle et alkynyle; et R2 et R3 forment ensemble -(CH2)-(CH2)- ou -(CH)=(CH)-.
Oestergaard Nielsen Elsebet
Paul Redrobe John
Peters Dan
Mccarthy Tetrault Llp
Neurosearch A/s
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