C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C12N 15/82 (2006.01) C12N 15/90 (2006.01)
Patent
CA 2403140
The present invention relates to chromosomal vectors, in particular to human artificial chromosomes, which are efficiently transmitted through the male and female germ line in each generation. The vectors are also transmitted through mitosis in substantially all dividing cells and provide a position independent expression of an exogenous DNA sequence. These vectors can be used in gene therapy and are useful for the production of transgenic animals and plants and products thereof.
L'invention concerne de nouveaux vecteurs chromosomiques et en particulier les chromosomes artificiels humains, qui sont efficacement transmis via la lignée germinale mâle et femelle à chaque génération. Les vecteurs sont également transmis via la mitose dans la quasi totalité des cellules en mitose et donnent une expression indépendante de position d'une séquence d'ADN exogène. Ces vecteurs peuvent être utilisés en thérapie génique et dans la production d'animaux et de plantes transgéniques et de produits de celles-ci.
Marynen Peter
Vermeesch Joris
Voet Thierry
Fetherstonhaugh & Co.
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (vib)
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