Novel cis-imidazolines

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 233/22 (2006.01) A61K 31/4164 (2006.01) A61P 35/00 (2006.01) C07D 233/26 (2006.01)

Patent

CA 2565189

Formula (I) and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3,Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proiferative activity.

La présente invention concerne au moins une composé choisi parmi les composés représentés dans la formule (I) et des esters et des sels pharmaceutiquement acceptables de ceux-ci; dans cette formule X¿1?, X¿2?, X¿3?,Y¿1?, Y¿2? et R sont tels que définis dans la description et ils bloquent l'interaction de la protéine MDM2 et d'un peptide de type p53, et ils présentent une activité antiproliférative.

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