Novel class ii cytokine receptors and uses thereof

Details Novel class ii cytokine receptors and uses thereof Novel class ii cytokine receptors and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/715 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 37/00 (2006.01) C07K 14/54 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2454802

A new class II cytokine receptor has been identified, which comprises an interleukin-22 receptor molecule, and an interleukin-20 receptor .beta. molecule. The complex binds to cytokines homologous to IL-10, including mda-7 and IL-20. Also described are methods for inhibiting effect of interleukin-20, mda-7, and IL-19 on cells. The latter is especially useful in treatment of, e.g., skin diseases such as psoriasis.

Selon l'invention, un nouveau récepteur de la cytokine de classe II a été identifié. Ce récepteur comprend une molécule réceptrice de l'interleukine-22, et une molécule .beta. réceptrice de l'interleukine-20. Le complexe se lie à des cytokines homologues à IL-10, notamment mda-7 et IL-20. L'invention concerne également des procédés inhibant l'effet de l'interleukine-20, mda-7, et IL-19 sur les cellules. Ce dernier est spécialement utile dans le traitement, p.ex., des maladies cutanées telles que le psoriasis.

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