C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/02 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C12M 1/34 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2400117
A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific to these proteins; and methods of diagnosing treating and preventing Alzheimer's disease by using the same.
L'invention concerne une nouvelle protéine humaine CLAC du type collagène présente dans les amyloïdes du cerveau et son précurseur CLAC-P, des gènes codant pour ladite protéine, un ADNc du précurseur CLAC-P de souris et sa séquence d'acides aminés déduits, et des anticorps spécifiques de ces protéines. L'invention concerne également des méthodes de diagnostic, de traitement, et de prévention de la maladie d'Alzheimer à l'aide de ladite protéine.
Hashimoto Tadafumi
Iwatsubo Takeshi
Nagai Yasuo
Bf Research Institute Inc.
Eisai R&d Management Co. Ltd.
Fetherstonhaugh & Co.
Iwatsubo Takeshi
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