Novel combination of benzoquinazoline antifolates and...

A - Human Necessities – 61 – K

Patent

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A61K 31/505 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2152507

The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmaceutical formulations comprising such combinations are disclosed.

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