Novel complex-forming proteins

Details Novel complex-forming proteins Novel complex-forming proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 19/00 (2006.01) C12N 15/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2359479

The invention relates to a complex comprised of unnaturally occurring, specifically complex-forming proteins containing the following components: a) at least one ligand which is specific for a target structure; b) at least one protein containing a mutated dimerization domain, whereby the mutated dimerization domain has been derived by mutating a naturally occurring dimerization domain, said mutated dimerization domain being able to specifically interact with component c), and component b) is covalently bound to component a); c) at least one protein containing a mutated dimerization domain, whereby the mutated dimerization domain has been derived by mutating a naturally occurring dimerization domain, said mutated dimerization domain being able to specifically interact with component b), and component c) is covalently bound to component d), and; d) at least one effector. The invention also relates to the utilization and production of these complexes as well as to nucleic acid constructs which code for said proteins and to the use thereof.

L'invention concerne un complexe à base de protéines spécifiquement complexantes n'intervenant pas de manière naturelle, qui contiennent les constituants suivants: a) au moins un ligand spécifique d'une structure cible; b) au moins une protéine contenant un domaine de dimérisation muté, ledit domaine de dimérisation muté ayant été dérivé par mutation d'un domaine de dimérisation intervenant de manière naturelle, ledit domaine de dimérisation muté peut entrer de manière spécifique en interaction avec le constituant b) et le constituant c) est lié de manière covalente au constituant d); et d) au moins un effecteur. L'invention concerne en outre l'utilisation et la préparation de ces complexes, ainsi que des produits de recombinaison d'acide nucléique codant pour les protéines mentionnées et leur utilisation.

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