Novel composition

Details Novel composition Novel composition

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2534546

An oral dosage form comprising a first composition and a second composition, each composition comprising a pharmaceutically acceptable weak base, especially Compound A or a pharmaceutically acceptable salt or solvate thereof, ('the drug') and a pharmaceutically acceptable carrier therefor, wherein the first and second compositions are arranged to release drug at differing release rates on administration such that the rate of release of the drug from the dosage form is substantially independent of pH; a process for preparing such a dosage form and the use of such a dosage form in medicine.

L'invention concerne une forme posologique orale qui contient une première composition et une seconde composition, chaque composition contenant une base faible acceptable sur le plan pharmaceutique, en particulier le composé A ou un sel ou un solvate de celui-ci acceptable sur le plan pharmaceutique, (<= le médicament >=) etun vecteur associé acceptable sur le plan pharmaceutique. Les première et seconde compositions sont conçues pour libérer le médicament à des vitesses différentes après la prise de sorte que la vitesse de libération du médicament de la forme posologique soit sensiblement indépendante du pH. Par ailleurs, l'invention concerne un procédé de préparation de cette forme posologique ainsi que son utilisation en médecine.

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