A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 9/00 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2418135
The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH3-(CH2)n-CH2OH or saturated fatty acid CH3-(CH2)n-CH2COOH wherein n is an integer number 8 ÷ 22, preferably 8 ÷ 12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH3(CnH2(n-1))-OH or CH3(CnH2(n-1))-COOH wherein n is an integer number 8 ÷ 22, b) a ternary vehicle or carrier consisting of a C1 ÷ C4 alkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol.
L'invention concerne une composition pharmaceutique destinée à l'administration transdermique ou transmuqueuse d'un ou de plusieurs agents actifs et se présentant sous forme d'un gel ou d'une solution comprenant comme promoteurs de perméation une combinaison de: a) un alcool gras saturé de formule CH¿3?-(CH¿2?)¿n?-CH¿2?OH ou un acide gras saturé CH¿3?-(CH¿2?)¿n?-CH¿2?COOH, où n est un nombre entier de 8 ÷ 22, de préférence 8 ÷ 12, et mieux encore 10, ou bien un alcool gras non saturé ou un acide gras non saturé de formule: CH¿3?(C¿n?H¿2(n-1)?)-OH ou CH¿3?(C¿n?H¿2(n-1)?)-COOH, où n est un nombre entier de 8 ÷ 22, b) un excipient ou support ternaire consistant en un alcanol C¿1? ÷ C¿4?, un polyalcool notamment un propylèneglycol et de l'eau, c) éventuellement aussi un monoalkyléther de diéthylèneglycol.
Carrara Dario
Porto Gabriel
Rodriguez Jorge
Antares Pharma Ipl Ag
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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