Novel compositions and methods in cancer

A - Human Necessities – 61 – K

Patent

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A61K 39/00 (2006.01)

Patent

CA 2572509

The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

La présente invention concerne de nouvelles séquences destinées à être utilisées dans la détection, le diagnostic et le traitement de cancers, notamment de lymphomes. L'invention concerne également des séquences polynucléotidiques associées au cancer (CA) dont l'expression est associée au cancer. La présente invention concerne par ailleurs des polypeptides CA associés au cancer qui présentent de nouvelles cibles thérapeutiques dirigées contre le cancer. La présente invention concerne aussi des compositions et des méthodes de diagnostic pour la détection du cancer. La présente invention concerne en outre des anticorps monoclonaux et polyclonaux spécifiques des polypeptides CA. La présente invention concerne enfin des outils de diagnostic ainsi que des compositions thérapeutiques et des méthodes de dépistage, de prévention et de traitement du cancer.

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