Novel compositions and methods of use

Details Novel compositions and methods of use Novel compositions and methods of use

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) C07D 471/02 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2711500

Described herein are novel enzyme inhibitors. In some embodiments the enzyme inhibitors are integrase inhibitors, particularly HIV integrase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV integrase as a method of treating or preventing HIV, AIDS or related disorders.

L'invention porte sur de nouveaux inhibiteurs d'enzyme. Dans certains modes de réalisation, les inhibiteurs d'enzyme sont des inhibiteurs d'intégrase, en particulier des inhibiteurs d'intégrase du VIH. L'invention porte également sur des compositions les contenant et sur des procédés les utilisant. Ainsi, les composés et les compositions décrits ici sont utiles pour l'inhibition in vitro et in vivo de l'intégrase du VIH en tant que procédé de traitement ou de prévention du VIH, du SIDA ou des troubles apparentés.

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