C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 313/00 (2006.01) A61K 31/365 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/435 (2006.01)
Patent
CA 2400896
Dictyostatin-1 has been found to stabilize microtubules and prohibit their depolymerization to free tubulin. Because of these activities, the dictyostatin compounds can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug- resistant cancers, autoimmune disorders, and inflammatory diseases.
Selon l'invention, on a découvert que la dictyostatine-1 stabilise les microtubules et empêche leur dépolymérisation en tubuline libre. Grâce à ces propriétés, les composés de dictyostatine peuvent être utilisés dans le traitement d'une pluralité de maladies impliquant une prolifération cellulaire aberrante, et notamment dans le traitement de cancers sensibles ou résistants aux médicaments, de troubles auto-immuns et de maladies inflammatoires.
Cummins Jennifer L.
Isbrucker Richard A.
Longley Ross E.
Pomponi Shirley A.
Wright Amy E.
Harbor Branch Oceanographic Institution Inc.
Mbm Intellectual Property Law Llp
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