A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 48/00 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2200952
The present invention provides compositions and methods which are useful for the introduction of polyanionic materials into cells. The compositions are mixtures of cationic compounds and neutral lipids which are typically formulated as liposomes. The cationic compounds are quaternary ammonium compounds wherein the nitrogen has two attached long chain alkyl groups, at least one of which is unsaturated. The methods for transfecting cells involve (a) contacting the polyanionic materials with the compositions above to form a polyanionic material-liposome complex, and (b) contacting the complex with the cells to be transfected.
La présente invention se rapporte à des compositions et des procédés permettant d'introduire des substances polyanioniques dans des cellules. Ces compositions sont des mélanges de composés cationiques et de lipides neutres généralement formulés sous forme de liposomes. Les composés cationiques sont des composés d'ammonium quaternaire dans lesquels l'azote renferme deux groupes alkyle à chaînes longues liés, dont au moins un est insaturé. Les procédés permettant de transfecter des cellules consistent à (a) mettre en contact les substances polyanioniques avec les compositions précitées pour former un complexe substance polyanionique/liposome, et (b) mettre ce complexe en contact avec les cellules à transfecter.
Ansell Steven Michial
Hope Michael
Mui Barbara
Fetherstonhaugh & Co.
Inex Pharmaceuticals Corp.
Tekmira Pharmaceuticals Corporation
LandOfFree
Novel compositions comprising quaternary ammonium compounds... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel compositions comprising quaternary ammonium compounds..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel compositions comprising quaternary ammonium compounds... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1962079