A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/727 (2006.01) A61K 9/22 (2006.01) A61K 47/02 (2006.01) A61K 47/06 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2379982
This invention relates to a composition for controlled release of a biologically active agent from a carrier. The biologically active agent is heparin or a related biologically active acidic polysaccharide and the carrier is a sol-gel derived silica xerogel. The xerogel is derived from a tetraalkoxysilane such as tetrethoxysilane (TEOS) and part of the tetraalkoxysilane is preplaced by an organomodified alkoxysilane, preferably an alkylsubstituted alkoxysilane. The invention also concerns a method for the preparation of said composition.
Cette invention porte sur une composition utilisée pour la libération régulée d'un agent biologiquement actif à partir d'un excipient. Cet agent biologiquement actif est l'héparine ou un polysaccharide acide biologiquement actif apparenté, et l'excipient est un xérogel de silice dérivé d'un sol-gel. Le xérogel est dérivé d'un tétraalcoxysilane tel que le tétraéthoxysilane (TEOS) et une partie de tétraalcoxysilane est remplacée par un alcoxysilane organomodifié, de préférence un alcoxysilane alkylsubstitué. L'invention concerne également un procédé de préparation de cette composition.
Ahola Manja
Penttinen Risto
Sailynoja Eija
Salonen Jukka
Yli-Urpo Antti
Bioxid Oy
Robic
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