A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/065 (2006.01) A61K 31/353 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2595159
Provided herein are methods and compositions for treating or preventing neurodegenerative disorders or blood coagulation disorders. Methods may comprise modulating the activity or level of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell with a sirtuin activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as nicotinamide.
L'invention concerne des méthodes et des compositions permettant de prévenir et de traiter des troubles de la neurodégénérescence et de la coagulation du sang. Ces méthodes peuvent consister à moduler l'activité ou le niveau de la sirtuine tels que SIRTl ou Sir2. A titre d'exemple, ces méthodes peuvent consister à mettre une cellule en contact avec un composé activant la sirtuine flavone, stilbène, flavanone, isoflavone, catéchine, chalcone, tannine ou anthocyanidine, notamment - ou bien avec un composé inhibitoire tel que le nicotinamide.
Dipp Michelle
Elliot Peter
Fujii Jennifer
Milburn Michael
Milne Jill
Borden Ladner Gervais Llp
Sirtris Pharmaceuticals Inc.
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