Novel compound amycolamicin, method for production thereof,...

C - Chemistry – Metallurgy – 12 – P

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C12P 17/16 (2006.01) A61K 31/4025 (2006.01) A61P 31/04 (2006.01) C07D 405/14 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2759679

Disclosed are: a novel compound which has an excellent antibacterial activity against a wide variety of pathogenic bacteria including drug-resistant bacteria and bacteria causing pneumonia in domestic livestock, a tautomer of the compound, or a salt of the compound or the tautomer; a method for producing the compound, the tautomer or the salt; and others. Specifically disclosed are: a compound characterized by being represented by structural formula (1), a tautomer of the compound, or a salt of the compound or the tautomer; a method for producing the compound, the tautomer or the salt, which is characterized by culturing a microorganism belonging to the genus Amycolatopsis and capable of producing the compound, the tautomer or the salt to produce a culture, and collecting the compound, the tautomer or the salt from the culture; and others.

Cette invention concerne un nouveau composé qui a une excellente activité antibactérienne contre une large gamme de bactéries pathogènes, notamment les bactéries pharmacorésistantes et les bactéries responsables de la pneumonie chez les animaux d'élevage, un tautomère du composé, ou un sel du composé ou du tautomère; un procédé de production du composé, du tautomère ou du sel; et d'autres composés. L'invention concerne spécifiquement : un composé caractérisé par la formule structurelle (1), un tautomère du composé, ou un sel du composé ou du tautomère; un procédé de production du composé, du tautomère ou du sel, caractérisé par la mise en culture d'un micro-organisme appartenant au genre Amycolatopsis et capable de produire le composé, le tautomère ou le sel pour produire une culture, et la collecte du composé, du tautomère ou du sel à partir de la culture; et d'autres composés.

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