C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/10 (2006.01) A61K 31/35 (2006.01) A61K 31/36 (2006.01) A61P 19/10 (2006.01) C07D 493/02 (2006.01) C07D 493/04 (2006.01)
Patent
CA 2742364
Provided are a novel compound with a spiro chiral carbon backbone, a stereoisomer thereof, an enantiomer thereof, an in vivo hydrolysable precursor thereof, or a pharmaceutically acceptable salt thereof. The novel compound with the spiro chiral carbon backbone has excellent osteoblast differentiation activity, mast cell inhibitory activity, and fatty acid synthesis inhibitory activity in the liver. Therefore, the novel compound can be expected to play an innovative role in treatment of osteoporosis, fatty liver, and obesity.
La présente invention concerne un nouveau composé à squelette de carbone chiral spiro, son procédé de préparation, ses diastéréoisomères, énantiomères, ses précurseurs hydrolysables in vivo, ou ses sels pharmaceutiquement acceptables. Le nouveau composé à squelette de carbone chiral spiro présente une excellente activité de différenciation d'ostéoblastes, une excellente activité inhibitrice de mastocytes, et une excellente activité inhibitrice de synthèse des acides gras dans le foie. Par conséquent, le nouveau composé peut être très utile dans le traitement de l'ostéoporose, de la stéatose hépatique, et de l'obésité.
Hong Jeong-Ho
Hong Jun-Young
Kang Heon-Joong
Kim Eun-O
Kim Jeong-Ah
Cassan Maclean
Snu R&db Foundation
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