Novel compounds

Details Novel compounds Novel compounds

C - Chemistry, Metallurgy

07

D

C07D 211/86 (2006.01) A61K 31/4412 (2006.01) A61P 29/00 (2006.01) C07D 241/08 (2006.01)

Patent

CA 2538405

There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.

Cette invention concerne des nouveaux composés représentés par la formule (I), dans cette formule, R?1¿, R?2¿, R?4¿, R?5¿, G?1¿, G?2¿, L, Y et n sont tels que définis dans la spécification, ainsi que des isomères optiques, des racémates et des tautomères de ceux-ci, et des sels pharmaceutiquement acceptables de ceux-ci. L'invention concerne également des procédés permettant de préparer de tels composés, ainsi que des compositions les contenant et leur utilisation à des fins thérapeutiques. Les composés décrits dans cette invention sont des inhibiteurs de l'élastase neutrophile.

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