Novel compounds

Details Novel compounds Novel compounds

C - Chemistry, Metallurgy

07

D

C07D 225/06 (2006.01) A61K 31/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2651558

The present invention relates to 18,21-didesoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular, in the treatment and/or prophylaxis of cancer or B-cell malignancies. Formula (I) wherein: R1 represents H, OH, OMe; R2 represents H or Me; R3 represents H or CONH2; R4 and R5 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); R6 represents H or F; R7 represents H or F; and R8 represents H or F.

L'invention concerne des analogues de 18,21-didesoxymacbécine que l'on utilise, par exemple, dans le traitement du cancer, de malignités touchant les lymphocytes B, le paludisme, d'infection fongique, de maladies du système nerveux central et neurodégénératives, de maladies dépendant de l'angiogenèse, de maladies auto-immunes et/ou comme prétraitement prophylactique du cancer. L'invention concerne également des procédés de production de ces composés et leur utilisation en médecine, notamment pour le traitement et/ou la prophylaxie du cancer ou de malignités touchant des lymphocytes B.

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