Novel compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/12 (2006.01) A61K 31/365 (2006.01) A61K 31/4427 (2006.01) A61P 35/04 (2006.01) C07D 313/00 (2006.01)

Patent

CA 2652399

The present invention relates to derivatives of borrelidin that are useful in medicine, e.g. in the treatment of cancer or B-cell malignancies, or other diseases in which angiogenesis contributes to the pathology including ophthalmic disorders such as diabetic retinopathy as well as age related macular degeneration (AMD), corneal neovascularisation and retinopathy or prematurity. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies and other diseases in which angiogenesis is implicated in the pathogenic process.

La présente invention concerne des dérivés de borrelidine qui sont utiles en médecine, par exemple pour le traitement d'un cancer ou de malignités des lymphocytes B, ou encore d'autres maladies au cours desquelles l'angiogenèse conduit à une pathologie, y compris les troubles ophtalmiques tels qu'une rétinopathie diabétique, une dégénérescence maculaire liée au vieillissement (AMD), une néovascularisation cornéenne, une rétinopathie ou une prématurité. La présente invention concerne également des procédés permettant de produire ces composés et leur utilisation en médecine, en particulier dans le traitement et/ou la prophylaxie d'un cancer ou de malignités des lymphocytes B, et d'autres maladies impliquant l'angiogenèse dans le processus pathogène.

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