C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/74 (2006.01) A61K 31/166 (2006.01) A61K 31/351 (2006.01) A61K 31/4015 (2006.01) A61K 31/4402 (2006.01) A61K 31/4465 (2006.01) A61K 31/535 (2006.01) C07D 207/27 (2006.01) C07D 211/22 (2006.01) C07D 211/96 (2006.01) C07D 213/30 (2006.01) C07D 213/61 (2006.01) C07D 295/088 (2006.01) C07D 309/06 (2006.01) C07D 309/12 (2006.01)
Patent
CA 2675669
Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11.beta.-hydroxysteroid dehydrogenase type 1 (11.beta.HSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.
La présente invention concerne de nouveaux inhibiteurs à base de benzamides substitués, leur utilisation thérapeutique, des compositions pharmaceutiques contenant ces composés, l'utilisation de ces composés dans la fabrication de médicaments, ainsi que des méthodes de traitement comprenant l'administration de ces composés. Les composés de cette invention modulent l'activité de la 11.beta.-hydroxystéroïde déshydrogénase de type 1 (11.beta.HSD1) et sont ainsi utilisés dans le traitement de maladies dans lesquelles une telle modulation est bénéfique, telles que le syndrome métabolique.
High Point Pharmaceuticals Llc
Smart & Biggar
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