Novel compounds and compositions as cathepsin inhibitors

Details Novel compounds and compositions as cathepsin inhibitors Novel compounds and compositions as cathepsin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 263/56 (2006.01) C07D 271/10 (2006.01) C07D 295/18 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2547591

Novel difluorinated amide derivatives of Formula (II) as inhibitors of cathepsin S, K, B, and L, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

L'invention concerne de nouveaux dérivés d'amide difluoré de la formule II en tant qu'inhibiteurs de la cathepsine S, K, B et L, leurs sels pharmaceutiquement acceptables et leurs <I>N</I>-oxydes, leurs utilisations comme agents thérapeutiques ainsi que leurs procédés de fabrication.

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