C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/16 (2006.01) A61K 31/13 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 247/14 (2006.01) C07D 203/26 (2006.01) C07D 211/72 (2006.01) C07D 211/92 (2006.01) C07D 309/28 (2006.01) C07D 335/02 (2006.01) C07D 405/00 (2006.01)
Patent
CA 2188835
Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
L'invention décrit de nouveaux composés qui sont généralement constitués d'un groupe acide, d'un groupe basique, d'un amino ou N-acyle substitué et d'un groupe doté d'une fraction alcanique éventuellement hydroxylée. L'invention comprend également des compositions pharmaceutiques constituées des inhibiteurs de ces composés et des méthodes conçues pour inhiber la neuraminidase dans les échantillons que l'on soupçonne de contenir de la neuraminidase. L'invention décrit également des matériaux antigènes, des polymères, des anticorps et des conjugués desdits composés ainsi que des traceurs et des méthodes de dosage destinés à la détection d'activité neuraminidase.
Bischofberger Norbert W.
Kim Choung U.
Lew Willard
Liu Hongtao
Williams Matthew A.
Gilead Sciences Inc.
Robic
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