Novel compounds and their use

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 413/10 (2006.01)

Patent

CA 2692255

The present invention provides novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The novel compounds are useful as antibacterial agents in the treatment of conditions such as nosocomial pneumonia, community acquired pneumonia, infections caused by vancomycin resistant enterococci (VRE), methicillin resistant Staphylococcus aureus (MRSA), Heamophilus influenzae (HI) and penicillin resistant Streptococcus pneumoniae (PRSP). The compounds of the present invention are effective against a number of human or animal pathogens including VRE, PRSP, HI and MRSA.

La présente invention concerne de nouveaux composés représentés par la formule générale (i), leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, hydrates, solvates, sels pharmaceutiquement acceptables ainsi que leurs compositions, métabolites et promédicaments. Les nouveaux composés se révèlent utiles en tant qu'agents antibactériens pour le traitement de pathologies telles qu'une pneumonie nosocomiale, une pneumonie acquise dans la collectivité, des infections causées par des entérocoques résistants à la vancomycine (ERV) et des bactéries telles que Staphylococcus aureus résistant à la méthicilline (SARM), Heamophilus influenzae (HI) et Streptococcus pneumoniae résistant à la pénicilline (SPRP). Les composés de la présente invention se révèlent efficaces contre un certain nombre de pathogènes humains ou animaux, notamment ERV, SPRP, HI et SARM.

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