Novel compounds and their use as glycine transport inhibitors

Details Novel compounds and their use as glycine transport inhibitors Novel compounds and their use as glycine transport inhibitors

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01) A61K 31/198 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61P 25/00 (2006.01) C07C 211/03 (2006.01) C07C 229/02 (2006.01) C07C 229/14 (2006.01) C07C 255/58 (2006.01) C07D 333/72 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2416447

The invention provides novel compounds of the formula I below: (I), wherein the meaning of each substituent is defined in the application. The compounds are useful as inhibitors of the glycine transporter and useful in the treatment of diseases responsive to the inhibition of the glycine transporter. The invention provides a pharmaceutical composition comprising a compound of Formula I as defined above and the use of compounds as above for the manufacture of medicaments for treatment of diseases responsive to ligands of the glycine transporter.

L'invention concerne de nouveaux composés de formule (I) dans laquelle les désignations de chaque substituant sont spécifiées dans la description. Les composés sont utilisés comme inhibiteurs de transporteur de glycine et dans le traitement de maladies influencées par l'inhibition du transporteur de glycine. L'invention concerne également une composition pharmaceutique comprenant un composé de formule (I) tel que défini précédemment et l'utilisation des composés précités pour la fabrication de médicaments pour le traitement de maladies influencées par des ligands du transporteur de glycine.

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