Novel compounds as anti-inflammatory, immunomodulatory and...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 233/60 (2006.01) A61K 31/185 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07C 233/58 (2006.01) C07C 233/59 (2006.01) C07C 233/62 (2006.01) C07C 255/60 (2006.01) C07C 323/40 (2006.01) C07D 307/30 (2006.01) C07D 333/38 (2006.01) C07D 333/58 (2006.01) C07D 335/12 (2006.01)

Patent

CA 2452491

The present invention relates to compounds of the general formula (I); or salts thereof, as anti-inflammatory, immunomodulatory and anti-proliferatory agents.

La présente invention concerne des composés représentés par la formule générale (I) ou certains de leurs sels. Dans cette formule, A est un système cyclique non-aromatique en C¿5? portant au moins une double liaison, l'un des atomes de carbones du cycle pouvant être remplacé par un groupe X appartenant à l'ensemble formé par les S, O, N, NR¿4?, SO et SO¿2?, l'un au moins des atomes de carbones du cycle pouvant en outre porter un R?1¿ substituant. D est O, S, SO¿2?, NR?4¿, ou CH¿2?. Z?1¿ et Z?2¿ sont indépendamment O, S, ou NR?5¿. R?1¿ est indépendamment H, halogène, haloalkyle, haloalkyloxy ou alkyle. R?2¿ est H ou OR?6¿. R?3¿ est H, alkyle, cycloalkyle, aryle, alcoxy, O-aryle, O-cycloalkyle, halogène, aminoalkyle, alkylamino, hydroxylalkyle, haloalkyloxy, hétéroaryle, alkylthio, S-aryle, S-cycloalkyle, arylalkyle, ou haloalkyle.

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