Novel compounds as histone deacetylase inhibitors

Details Novel compounds as histone deacetylase inhibitors Novel compounds as histone deacetylase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2491131

The present invention is directed to compounds of the general formula (I) or pharmaceutical acceptable salts or physiologically functional derivatives thereof wherein: n is a non-aromatic ring system containing two to seven carbon atoms, wherein the ring system can contain one ore two double bonds; X is C, CH or CH2; Y is selected from C, CH, CH2, S, NR, CH2-CH2, H2C- -CH, HC- - CH2, C- -CH2, H2C- -C,or C - -C; one or more of the hydrogen atoms can opionally be substituted by one or more substituents R ; each of the dotted lines means a single, a double or triple bond with the exclusion of a combination of a triple with triple bond and a double with a triple bond; R is independently H, -CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, -OH, - SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogene, haloalkyl, haloalkyloxy; R is H, an alkyl or cycloalkyl group; Z is CH, C, or P; p is 0 or 1.

La présente invention concerne des composés correspondant à la formule générale (I), ou bien des sel pharmaceutiquement acceptables ou des dérivés physiologiquement fonctionnels de ces composés. Dans ladite formule (I): n représente un cycle non aromatique contenant deux à sept atomes de carbone, le système cyclique pouvant contenir au moins deux doubles liaisons; X représente C, CH ou CH¿2?; Y est sélectionné parmi C, CH, CH¿2?, S, NR, CH¿2?-CH¿2?, H¿2?C- -CH, HC- -CH¿2?, C- -CH¿2?, H¿2?C- -C, ou bien C- -C, au moins un des atomes hydrogènes pouvant être éventuellement substitué par au moins un substituant R'; chacune des lignes pointillées représente une liaison simple, double ou triple, une combinaison d'une triple liaison et d'une triple liaison, ainsi que d'une double liaison et d'une triple liaison étant exclue; les symboles R' représentent, indépendamment l'un de l'autre, H, -CN, alkyle, cycloalkyle, aminoalkyle, alkylamino, alcoxy, -OH, -SH, alkylthio, hydroxyalkyle, hydroxyalkylamino, halogène, haloalkyle, haloalkyloxy; R représente H, un groupe alkyle ou cycloalkyle; Z représente CH, C, ou P; p vaut 0 ou 1.

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