Novel compounds for treatment of cancer and disorders...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01) C07C 243/24 (2006.01) C07D 215/00 (2006.01) C07D 231/14 (2006.01) C07D 239/84 (2006.01) C07D 275/06 (2006.01) C07D 311/04 (2006.01) C07D 471/14 (2006.01) C07D 473/06 (2006.01) C07D 487/14 (2006.01) C07D 495/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2586080

Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.

La présente invention concerne de nouveaux composés utiles pour le traitement du cancer et des troubles associés à la fonction d'angiogenèse; une méthode de préparation des composés, des compositions pharmaceutiques et des produits conditionnés contenant lesdits composés, une méthode d'utilisation de ces molécules pour traiter le cancer (par exemple la leucémie, le cancer bronchopulmonaire 'non à petites cellules'', le cancer du côlon, le cancer du système nerveux central, le mélanome, le cancer de l'ovaire, le cancer du sein, le cancer du rein et le cancer de la prostate) et les troubles associés à la fonction d'angiogenèse (par exemple la dégénérescence maculaire liée à l'âge, la dystrophie maculaire et le diabète), une méthode de surveillance du traitement, une méthode d'établissement de profils de l'expression génique et une méthode de modulation de la croissance cellulaire, du cycle cellulaire, de l'apoptose ou de l'expression génique.

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