Novel compounds having selective inhibiting efect at gsk3

Details Novel compounds having selective inhibiting efect at gsk3 Novel compounds having selective inhibiting efect at gsk3

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 5/48 (2006.01) A61P 15/18 (2006.01) A61P 17/14 (2006.01) A61P 25/00 (2006.01) C07D 241/26 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 409/06 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2508045

The present invention relates to new compounds of formula (I) wherein Z is N; Y is CONR5, NR5CO, SO2NR5, NR5SO2, CH2NR5, NR5, NR5CONR5, CH2CO, CO, O or CH2O; X is CH or N; P is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S and said phenyl ring or 5 or 6 membered heteroaromatic ring may optionally be fused with a 5 or 6 membered saturated, partially saturated or unsaturated ring containing one or more atoms selected from C, N, O or S; Q is C1-6alkyl, C2-6alkenyl or C2-6alkynyl, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy, such as provide compounds having a selective inhibiting effect at GSK3.

La présente invention concerne de nouveaux composés représentés par la formule suivante (I). Dans cette formule Z est N; Y est CONR¿5?, NR¿5?CO, SO?2#191NR¿5?, NR¿5<SP>SO2#191, CH2#191NR</SP>5?, NR¿5?, NR¿5<SP>CONR</SP>5?, CH2#191CO, CO, O ou CH2#191O; X est CH ou N; P est phényle ou un cycle hétéroaromatique à 5 ou 6 branches contenant un ou plusieurs hétéroatomes sélectionnés parmi N, O ou S et ce cycle phényle ou ce cycle hétéroaromatique à 5 ou 6 branches peut éventuellement être fusionné avec un cycle à 5 ou 6 branches saturé, partiellement saturé ou non saturé contenant un ou plusieurs atomes sélectionnés parmi C, N, O ou S; Q est C1-6#191alkyle, C2-6#191alkényle ou C2-6#191alkynyle. Cette invention concerne aussi un processus de préparation de ces composés et de nouveaux intermédiaires utilisés dans cette préparation, des préparations pharmaceutiques contenant ces composés thérapeutiquement actifs et l'utilisation de ces composés dans une thérapie, de façon à fournir des composés possédant un effet inhibiteur sélectif à la protéine kinase GSK3.¿

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