C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/24 (2006.01) A61K 31/17 (2006.01)
Patent
CA 2601873
This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receotor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach- duodenal ulcer, inflammatory diseases, ear disease, and heart disease.
L'invention concerne des nouveaux composés, un isomère de ceux-ci ou des sels acceptables sur le plan pharmaceutique de ceux-ci utilisés en tant qu'antagoniste du récepteur vanilloïde (récepteur vanilloïde 1, VR1, TRPV1) ; et une composition pharmaceutique les contenant. L'invention concerne une composition pharmaceutique permettant de prévenir ou de traiter des maladies de type douleur, migraine, arthralgie, névralgie, neuropathie, lésion nerveuse, affection cutanée, hypersensibilité de la vessie, syndrome du côlon irritable, défécation impérieuse, trouble respiratoire, irritation de la peau, de l'oeil ou des muqueuses, ulcère gastroduodénal, maladie inflammatoire, maladie de l'oreille, et maladie cardiaque.
Bae Joon Ho
Choi Jin Kyu
Jeong Yeon Su
Kim Hee-Doo
Kim Jin Kwan
Amorepacific Corporation
Cassan Maclean
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