C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/24 (2006.01) A61K 31/17 (2006.01)
Patent
CA 2601871
This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receotor 1; VR1; TRPV1 )antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach- duodenal ulcer, inflammatory diseases, ear disease, and heart disease.
L'invention concerne de nouveaux composés, un isomère de ceux-ci ou des sels de ceux-ci acceptables sur le plan pharmaceutique utilisés en tant qu'antagoniste de récepteur vanilloïde (récepteur vanilloïde 1; VR1; TRPV1 ); et une composition pharmaceutique contenant ces composés. L'invention concerne également une composition pharmaceutique destinée à prévenir ou traiter une maladie telle que la douleur, la migraine, l'arthralgie, la névralgie, les neuropathies, les lésions nerveuses, les affections cutanées, l'hypersensibilité de la vessie, le syndrome du colon irritable, la défécation impérieuse, les troubles respiratoires, l'irritation de la peau, des yeux ou des muqueuses, l'ulcère gastro-duodénal, les maladies inflammatoires, les maladies de l'oreille, et les maladies cardiaques.
Choi Jin Kyu
Jang Mi Jung
Jeong Yeon Su
Kim Hee-Doo
Kim Jin Kwan
Amorepacific Corporation
Cassan Maclean
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