C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/16 (2006.01) A61K 31/401 (2006.01) A61K 31/445 (2006.01) A61K 31/5375 (2006.01) C07D 211/60 (2006.01) C07D 211/96 (2006.01) C07D 265/30 (2006.01)
Patent
CA 2565843
The present invention relates to compounds with the formulas (I), (II), and (III), or a pharmaceutically acceptable salt thereof: wherein T is a (4 to 10)- membered heterocyclyl selected from the group consisting of and wherein R1. R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formulas (I), (II), and (III) and methods of treating a condition that is mediated by the modulation of the 11-.beta.-hsd-1 enzyme, the method comprising administering to a mammal an effective amount of a compound of formulas (I), (II), and (III).
La présente invention a trait à des composés de formules (I), (II), et (II), dans lesquelles: T est un hétérocyclyle de 4 à 10 chaînons choisi parmi le groupe constitué de et dans lesquelles R?1¿, R?2¿ et R?3¿ sont tels que définis dans la description, ou un sel pharmaceutiquement acceptable de ceux-ci. L'invention a également trait à des compositions pharmaceutiques comportant des composés de formules (I), (II) et (III) et à des procédés de traitement d'une condition causée par l'intermédiaire de la modulation de l'enzyme 11-.beta.-hsd-1, le procédé comprenant l'administration à un mammifère d'une quantité efficace d'un composé de formules (I), (II) et (III).
Cheng Hengmiao
Cripps Stephan James
Dress Klaus Ruprecht
Hoffman Jacqui Elizabeth
Huang Buwen
Pfizer Inc.
Sim & Mcburney
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