Novel compounds of reverse turn mimetics and the use thereof...

Details Novel compounds of reverse turn mimetics and the use thereof... Novel compounds of reverse turn mimetics and the use thereof...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01)

Patent

CA 2701735

Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

L'invention concerne de nouveaux composés conformationnellement contraints qui imitent la structure secondaire de régions de coude inverse de peptides et de protéines biologiquement actifs et qui ont un squelette bicyclique, ainsi que leurs dérivés comprenant des promédicaments. Ces structures mimétiques de coude inverse et ces promédicaments sont utilisés dans une grande variété de domaines, notamment comme agents diagnostiques et thérapeutiques. L'invention concerne également l'utilisation de ces composés dans la préparation d'un médicament permettant de traiter ou prévenir un cancer tel que la leucémie myéloïde aiguë.

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