Novel compounds, pharmaceutical compositions containing...

C - Chemistry – Metallurgy – 07 – C

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C07C 311/01 (2006.01) A61K 31/195 (2006.01) A61K 31/662 (2006.01) A61P 3/04 (2006.01) C07C 311/15 (2006.01) C07F 9/38 (2006.01)

Patent

CA 2729767

The present invention relates to a novel class of compounds comprising formula I, wherein n is 0 or 1. A is NR1, O, or S, wherein R1 is H, hydroxyl, C1-C10 alkyl, C1-C10 alkoxy, alkenyl, aryl, alkylaryl or arylalkyl. X is a carboxylate, a phosphonate, or a phosphate residue, or a C1-C10 alkyl residue optionally substituted with a carboxylate, phosphonate or phosphate residue. Y is a C1-C20 alkyl, alkenyl, halide, hydroxyl, C1-C20 alkoxy, aryl, alkylaryl, arylalkyl, cycloalkyl, cycloalkenyl, or a heterocyclic ring and is optionally substituted with one or more halides. Z is a H, a hydroxyl group, a halide, an aryl group, an alkylaryl group, an arylalkyl group, a cycloalkyl group, a cycloalkenyl group or a heterocyclic ring and is optionally substituted with one or more C1-C10 alkyl groups, C1-C10alkoxy groups, hydroxyl groups, cyano groups, carboxylate groups, halides, aryl groups, alkylaryl groups, arylalkyl groups, cycloalkyl groups, cycloalkenyl groups or heterocyclic rings.

Cette invention concerne une nouvelle classe de composés de formule I. Dans la formule I, n vaut 0 ou 1 ; A est NR1, O, ou S, R1 étant H, un hydroxyle, alkyle C1-C10, alcoxy C1-C10, alcényle, aryle, alkylaryle ou arylalkyle ; X est un résidu carboxylate, phosphonate, ou phosphate, ou un résidu alkyle C1-C10 éventuellement substitué par un résidu carboxylate, phosphonate, ou phosphate ; Y est un alkyle C1-C20, alcényle, halogénure, hydroxyle, alcoxy  C1-C20, aryle, alkylaryle, arylalkyle, cycloalkyle, cycloalcényle, ou un cycle hétérocyclique et est éventuellement substitué par un ou plusieurs halogénures ; Z est H, un groupe hydroxyle, un halogénure, un groupe aryle, un groupe alkylaryle, un groupe arylalkyle, un groupe cycloalkyle, un groupe cycloalcényle ou un cycle hétérocyclique et est éventuellement substitué par un ou plusieurs groupes alkyle C1-C10, groupes alcoxy C1-C10, groupes hydroxyle, groupes cyano, groupes carboxylate, halogénures, groupes aryle, groupes alkylaryle, groupes arylalkyle, groupes cycloalkyle, groupes cycloalcényle ou cycles hétérocycliques.

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