C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/68 (2006.01) A61K 31/365 (2006.01) C07D 307/33 (2006.01)
Patent
CA 2491183
Pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula (IX): R29 = H, or CI-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, =CHR31, -C(O)OR31, - C(O)R31, -CH2C(O)OR31, CH2C(O)NHR31, where R31 is H or C1-C10 alkyl, cycloalkyl, or alkenyl; R30 = C1- C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl; X5 = -OR32, or NHR32, Where R32 is H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, the R32 group optionally containing a carbonyl group, a carboxyl group, a carboxyamide group, an alcohol group, or an ether group, the R32 group further optionally containing one or more halogen atoms; with the proviso that when R29 is =CH2, then X5 is not OH. Also disclosed are compounds within the scope of the formula (IX), as well as uses of the pharmaceutical compositions for weight loss, anti-microbial and anti-cancer applications, inhibition of fatty acid synthase and neuropeptide-Y, and the stimulation of the activity of carnitine palmitoyl transferase-1.
L'invention porte sur une composition pharmaceutique comprenant un diluant pharmaceutique et un composé de formule (IX): R?29¿ = H, or C<SB>I</SB>-C¿20? alkyle, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle, =CHR?31¿, -C(O)OR?31¿, - C(O)R?31¿, -CH¿2?C(O)OR?31¿, CH¿2?C(O)NHR?31¿, R?31¿ représentant H ou C¿1?-C¿10? alkyle, cycloalkyle ou alcényle; R?30¿ = C¿1?-C¿20? alkyle, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle; X?5¿ = -OR?32¿, ou NHR?32¿, R?32¿ représentant H, C¿1?-C¿20? alkyle, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle, le groupe R?32¿ contenant éventuellement un groupe carbonyle, un groupe carboxyle, un groupe carboxyamide, un groupe alcool ou un groupe éther, le groupe R?32¿ contenant également éventuellement un ou plusieurs atomes d'halogène; à condition que lorsque R?29¿ représente =CH¿2?, X?5¿ ne représente pas OH. L'invention porte également sur des composés de formule (IX), ainsi que sur les utilisations des compositions pharmaceutiques dans des applications de perte de charge pondérale, antimicrobiennes et anticancéreuses, dans l'inhibition de la synthase de l'acide gras et du neuropeptide-Y, et dans la stimulation de l'activité de la carnitine palmitoyl transférase-1.
Kuhadja Francis P.
Mcfadden Jill M.
Medghalchi Susan M.
Thupari Jagan N.
Townsend Craig A.
Fasgen Llc.
Smart & Biggar
The Johns Hopkins University
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