C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/32 (2006.01) A61K 31/38 (2006.01)
Patent
CA 2491802
A pharmaceutical composition comprising a phamaceurtical diluent and a compound of formula IV wherein R21= H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, -CH2OR25, -C(O)R25, -CO(O)R25, -C(O)NR25R26, - CH2C(O)R25, or -CH2C(O)NHR25, where R25 and R26 are each independently H, C1- C10 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R22 = -OH, -OR27, -OCH2C(O)R27, - OCH2C(O)NHR27, -OC(O)R27, -OC(O)OR27, -OC(O)NHNH-R5, or -OC(O)NR27R28, where R27 and R28 are each independentlyH, C1 -C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where R27 and R28 can each optionally contain halogen atoms; R23 and R24, the same or different from each other, are C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.
Composition pharmaceutique contenant un diluant pharmaceutique et un composé de formule (IV) dans laquelle R?21¿ représente H, alkyle C¿1-20?, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle, -CH¿2?OR?25¿, -C(O)R?25¿, -CO(O)R?25¿, -C(O)NR?25¿R?26¿, -CH¿2?C(O)R?25¿, ou -CH¿2?C(O)NHR?25¿, dans lesquelles R?25¿ et R?26¿ représentent chacun indépendamment H, alkyle C¿1-10?, cycloalkyle, alcényle, aryle, arylalkyle, ou alkylaryle, contenant éventuellement un ou plusieurs atomes d'halogène, R?22¿ représente -OH, -OR?27¿, -OCH¿2?C(O)R?27¿, -OCH¿2?C(O)NHR?27¿, -OC(O)R?27¿, -OC(O)OR?27¿, -OC(O)NHNH-R?5¿, ou -OC(O)NR?27¿R?28¿, dans lesquelles R?27¿ et R?28¿ représentent chacun indépendamment H, alkyle C¿1-20?, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle, R?27¿ et R?28¿ pouvant chacun contenir éventuellement des atomes d'halogène, R?23¿ et R?24¿, qu'ils soient identiques ou différents l'un de l'autre, représentent alkyle C¿1-20?, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle. Des méthodes d'utilisation de ces compositions pour traiter le cancer, pour engendrer une perte pondérale, pour traiter des infections microbiennes, pour inhiber le neuropeptide-Y et / ou l'acide gras synthase et pour stimuler CPT-1 sont également décrites.
Kuhajda Francis P.
Mcfadden Jill M.
Medghalchi Susan M.
Thupari Jagan
Townsend Craig A.
Fasgen Inc.
Smart & Biggar
The Johns Hopkins University
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