C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 207/34 (2006.01) C07D 209/42 (2006.01) C07D 209/88 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2414512
The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): wherein: Z1 and Z2 are independently-NR3- (wherein R3 is hydrogen or alkyl) or -O-; R1 and R2 are independently substituted alkyl, substituted aryl, heteroaryl, or substituted heteroaryl provided that at least one of R1 and R2 is a group that can form a pharmaceutically acceptable acid addition salt; R3 is hydrogen, alkyl or R3 and R1 or R2 together with the atoms to which they are attached form a heterocyclic ring; X2 is aryl, substituted aryl, heteroaryl, substituded heteroaryl, alkenyl, alkynyl, cycloalkyl or heterocyclic; X1 and X3 are independently aryl, substituted aryl, heteroaryl, substituted heteroaryl, or- CHR4, wherein R4 is natural or unnatural amino acid side chain; or a pharmaceutically acceptable acid addition salt thereof.Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
L'invention concerne des nouveaux composés possédant une ou plusieurs activités parmi les suivantes: des activités anti-bactérienne, antifongique et anti-tumeur. Les composés sont de formule (I). L'invention concerne également des compositions pharmaceutiques renfermant ces composés, des procédés de fabrication de ceux-ci, ainsi que des procédés d'utilisation de ces composés.
Botyanszki Janos
Dyatkina Natalia B.
Khorlin Alexander
Liehr Sebastian Johannes R.
Muchowski Joseph Martin
Genelabs Technologies Inc.
Ridout & Maybee Llp
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