C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 35/00 (2006.01) C07K 5/10 (2006.01)
Patent
CA 2219819
Novel dolasstatin derivatives of the formula (I): R1R2N-CHX-CO-A-B-D-E-(F)t K, in which R1, R2, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
L'invention concerne de nouveaux dérivés de la dolastatine de la formule (I): R<1>R<2>N-CHX-CO-A-B-D-E-(F)t-K, dans laquelle R<1>, R<2>, A, B, D, E, F, K, X et t ont la signification indiquée dans la description. L'invention concerne également la préparation desdits dérivés. Ces nouvelles substances ont un effet antinéoplasique.
Emling Franz
Haupt Andreas
Romerdahl Cynthia A.
Abbott Gmbh & Co. Kg.
Basf Aktiengesellschaft
Robic
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