Novel compounds, the preparation and use thereof

Details Novel compounds, the preparation and use thereof Novel compounds, the preparation and use thereof

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 35/00 (2006.01) C07K 5/10 (2006.01)

Patent

CA 2219818

Novel dolastatin derivatives of the formula (I): R1R2N-CHX-CO-A- B-D-E-(F)t-K in which R1, R2, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

La présente invention se rapporte à de nouveaux dérivés de dolastatine de formule (I): R<1>R<2>N-CHX-CO-A-B-D-E-(F)t-K, dans laquelle R<1>, R<2>, A, B, D, E, F, K, X et t sont tels que décrits dans la description. L'invention décrit également la préparation de ces dérivés. Ces nouvelles substances présentent un effet antinéoplasique.

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