C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/02 (2006.01) A61K 31/425 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 513/04 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2144545
A condensed thiazole derivative useful as a 5-HT3 receptor agonist represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, a process for the production thereof and a pharmaceutical composition thereof. Image (I) (Symbol in the formula have the following meanings; R: a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, a nitro group, an amino group, a cyano group or a protected hydroxyl group, Image : a phenyl ring or a naphthalene ring, L1 and L2: one is a direct bond and the other is a) a straight- or branched-lower alkylene group which may contain an interrupting oxygen or sulfur atom therein, b) an oxygen atom or a sulfur atom, or c) a lower alkenylene group, L: a direct bond or a straight- or branched-lower alkylene group, Im: a group represented by a formula Image or Image R1, R2 and R3: the same or different from one another, each representing a hydrogen atom or a lower alkyl group, and R4, R5 and R6: the same or different from one another, each representing a hydrogen atom or a lower alkyl group.)
Ito Hiroyuki
Iwaoka Kiyoshi
Koshio Hiroyuki
Miyata Keiji
Ohta Mitsuaki
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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