Novel coumarin derivative having antitumor activity

Details Novel coumarin derivative having antitumor activity Novel coumarin derivative having antitumor activity

C - Chemistry, Metallurgy

07

D

C07D 311/18 (2006.01) A61K 31/352 (2006.01) A61K 31/427 (2006.01) A61K 31/443 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 491/052 (2006.01)

Patent

CA 2640652

It is intended to provide a compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof. Because of having a sufficiently high antitumor activity, this compound or its salt is useful as a remedy for cell proliferative diseases, in particular, cancer. It is also intended to provide a medicinal composition which contains the above-described compound or its salt as the active ingredient. ¢Chemical formula 1! (1) wherein X is selected from heteroaryl, etc.; Y1 and Y2 are selected from -N=, etc.; Y3 and Y4 are selected from -CH=, etc.; A is selected from sulfamide, etc.; R1 is selected from hydrogen, etc.; and R2 is selected from C1-6 alkyl, etc.

L'invention concerne un composé représenté par la formule générale (1) suivante ou un de ses sels pharmaceutiquement acceptables. Du fait de son activité antitumorale suffisamment élevée, ce composé ou son sel est utile en tant que remède pour des maladies de prolifération cellulaire, notamment le cancer. L'invention concerne également une composition médicinale contenant le composé décrit précédemment ou son sel en tant qu'ingrédient actif. [Formule chimique 1] (1) dans laquelle X est choisi parmi hétéroaryle, entre autres ; Y1 et Y2 sont choisis parmi -N=, entre autres ; Y3 et Y4 sont choisis parmi -CH=, entre autres ; A est choisi parmi sulfamide, entre autres; R1 est choisi parmi hydrogène, entre autres ; et R2 est choisi parmi alkyle en C1-6, entre autres.

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