Novel crystal forms of...

Details Novel crystal forms of... Novel crystal forms of...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/501 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2736554

The present inventions are directed to novel crystal forms of 4-(2- aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,4,5,6-tetrahydro-6-oxopyridazin-3- yl)- 1H-pyrazole methanesulfonate, which is useful as a pharmaceutical product, and methods for their preparation. The present inventions provide two stable crystalline polymorphs called A--form crystal and B-form crystal as well as methods for their preparation, by which each crystalline polymorph can be individually obtained as a single crystal form.

La présente invention concerne de nouvelles formes cristallines de 4-(2-aminopyridin-4-yl)-3-(4-fluorophényl)-1-(1,4,5,6-tétrahydro-6-oxopyridazin-3-yl)-1H-pyrazole-méthanesulfonate, qui sont utiles en tant que médicaments ; et un procédé pour la production de celles-ci. Deux formes polymorphes stables appelées cristal de type A et cristal de type B ; et un procédé de production par lequel chacune des formes polymorphes peut être produite sous la forme dune forme polymorphe unique.

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