C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 501/22 (2006.01)
Patent
CA 2520083
A novel crystal (B-type crystal) of 7-[2-(2-aminothiazole-4-yl)-2- hydroxyiminoacetamide-3-vinyl-3-cephem-4-carboxylic acid (a syn isomer), characterized in that it exhibits peaks at diffraction angles shown in the following Table 1, in its powder X ray diffraction pattern; Table 1 Diffraction Angle 2.theta. (~) approximately 11.7 approximately 16.1 approximately 18.6 approximately 21.2 approximately 22.3 approximately 24.4 approximately 26.2 and a method for preparing the novel crystal which comprises forming a crystal from a solution at a temperature of -5 to 5~C in an acidic state. The crystal is not bulky, exhibits good stability and good filterability, and is excellent in the solubility toward water, and thus can be prepared with ease.
La présente invention concerne un nouveau cristal ( cristal de type B de 7-[2-(2-aminothiazole-4-yl)-2-hydroxyiminoacétamide-3-vinyl-3-céphem-4-acide carboxylique (un isomère synthétique), caractérisé en ce qu'il présente des sommets aux angles de diffractions (figurés sur le tableau 1 suivant), dans son diagramme de diffraction au rayon X sur poudre; Tableau 1 angle de diffraction 2.theta. (·) approximativement 11.7 approximativement 16.1 approximativement 18.6 approximativement 21.2 approximativement 22.3 approximativement 24.4 approximativement 26.2. Cette invention concerne aussi un procédé de préparation de ce nouveau cristal qui consiste à former un cristal à partir d'une solution à une température comprise entre -5 et +5 ·C dans un état acide. Ce cristal n'est pas volumineux, présente une bonne stabilité et une bonne capacité de filtrage et ile est excellent quant à sa solubilité dans l'eau et, on peut donc le préparer facilement
Imai Eiji
Niwa Hiroyuki
Acs Dobfar S.p.a.
Fetherstonhaugh & Co.
Sandoz Ag
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