C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/12 (2006.01)
Patent
CA 2652939
Disclosed is a crystal of 3-[5-[4-(cyclopentyloxy)-2- hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6- yl)methoxy]phenyl]propionic acid having refraction angles of 14.0, 16.0, 23.3, 23.7 and 26.3~ as measured in terms of 2.theta. in powder X-ray diffraction pattern. Also disclosed is a crystal of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3- hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid having refraction angles of 14.6, 23.1, 24.7, 25.6 and 26.0~ as measured in terms of 2.theta. in powder X-ray diffraction pattern. These crystals have small specific volumes, are hardly charged electrically, can be handled easily, and are useful as excellent active ingredients for anti-rheumatic drugs.
La présente invention concerne un cristal d'acide 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)méthoxy]phényl]propionique ayant des angles de réfraction de 14,0, 16,0, 23,3, 23,7 et 26,3° ainsi mesurés en termes de 2.theta. sur le diagramme de diffraction des rayons X sur poudre. La présente invention concerne en outre un cristal d'acide 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)méthoxy]phényl]propionique ayant des angles de réfraction de 14,6, 23,1, 24,7, 25,6 et 26,0° ainsi mesurés en termes de 2.theta. sur le diagramme de diffraction des rayons X sur poudre. Ces cristaux ont de petits volumes spécifiques, sont à peine chargés électriquement, peuvent être manipulés facilement, et sont utiles en tant qu'excellentes substances actives pour un médicament anti-rhumatismal.
Baba Yasutaka
Kotsubo Hironori
Tada Yukie
Yonezawa Kenji
Marks & Clerk
Toyama Chemical Co. Ltd.
Toyama Chemical Co. Ltd.
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