Novel crystal of 5-aminolevulinic acid phosphate and process...

C - Chemistry – Metallurgy – 07 – C

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C07C 229/22 (2006.01) A61K 31/19 (2006.01) A61P 7/02 (2006.01) A61P 7/06 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) B01D 9/02 (2006.01) C07C 227/42 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2650206

Disclosed are: a novel crystal of 5-aminolevulinic acid phosphate having high thermal stability, a high melting point and excellent water absorption resistance; and a process for producing the crystal. Specifically disclosed are: a crystal of 5-aminolevulinic acid phosphate, which has characteristic peaks at diffraction angle (2.theta.) = 7.9º ± 0.2º, 15.8º ± 0.2º, 18.9º ± 0.2º, 20.7º ± 0.2º, 21.2º ± 0.2º, 21.4º ± 0.2º, 22.9º ± 0.2º, 33.1º ± 0.2º and 34.8º ± 0.2º in a powder X-ray diffraction; and a process for producing the crystal.

La présente invention concerne un nouveau cristal de phosphate d'acide 5-aminolévulinique ayant une stabilité thermique élevée, un point de fusion élevé et une excellente résistance à l'absorption d'eau, ainsi qu'un procédé pour sa fabrication. L'invention concerne spécifiquement un cristal de phosphate d'acide 5-aminolévulinique possédant des pics caractéristiques à des angles de diffraction (2?) = 7,9 º ± 0,2 º, 15,8 º ± 0,2 º, 18,9 º ± 0,2 º, 20,7 º ± 0,2 º, 21,2 º ± 0,2 º, 21,4 º ± 0,2 º, 22,9 º ± 0,2 º, 33,1 º ± 0,2 º et 34,8 º ± 0,2 º dans une diffraction de rayonsX sur poudres, ainsi qu'un procédé pour sa fabrication.

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